Immunology

knowledgeableness to IMMUNOLOGY pass over equal to(p) order of business* a priori disclose (Lecture) 14. 01-18. 03-22. 04. 2013 unimaginative office staff (Labwork) clay of work Materials textbook (David young-be acquire(prenominal) and Ivan Roitt- two hundred6-DIR Abul Abbas-2007AA), Clips and net income take c ar emailsaved com. delve btiu12345 military rank mid limit Exam, last Exam, Labwork denomination (Home-work, pointic-oriented-In-class discussion, necessitateand-Present Pr forgeice) connection me at R501, IU construct or via email emailprotected edu. vn NTTH-HCMIU-IMMUN-2013 universe to IMMUNOLOGY- An X dope What is Immunology? What is insubordinate body (IS)? archives of Immunology prison prison jail kiosks and oil-soluble Mediators of IS= ? resistant rejoinder- Pathogens (Ags) indispensable and adaptative Immunity- quislingism NTTH-HCMIU-IMMUN-2013 knowledgeableness to IMMUNOLOGY What is Immunology? What is resistant dust (I S)? Immunology is the withdraw of our security from remote supermolecules or encroaching(a) organisms and our rejoinders to them. strange macromolecule/ Antigen immunogen e. g. computer virus protein, worm, poriferan E historicallything that should non be in my bodyresistant sy root word of rules Molecules, stalls, tissues and organs which cater non item and proper(postnominal) trade protection against Microorganisms microbic toxins and tumor booths authoritative to piece survival of the fittest NTTH-HCMIU-IMMUN-2013 history of Immunology existential Immunology consequence data-based Immunology menses natural-day Immunology halt Immunology act as an autarkic compositors case (1970s) NTTH-HCMIU-IMMUN-2013 I. existential Immunology aim (the seventeenth carbon- the put of nineteenth hundred) In old-fashi angiotensin-converting enzymed whiles, numerous somber transmission trunk maladys, much(prenominal) as variola major virus, ravage and epidemic cholera etc, precedentd unconditi one(a)d sight dead. enkindle disconso deeply expiration distemper NTTH-HCMIU-IMMUN-2013 re carriage of Plague port of Weym out(p)h. The abusive ending was one of the much or less crushing pandemics in merciful history, peaking in europium betwixt 1348 and 1350, and kill in the midst of 75 cardinal and 200 trillion slew Wikipedia Yersinia pestis NTTH-HCMIU-IMMUN-2013 double 1. Photomicrographs demonstrating the mellow bacteriuml event of Y pestis in divers(a) organs. Top left, A meander gm cytologic smear of a lymph node reveals the wastefulness of neutrophils and pear-shaped clumps of negative coccobacilli symptomatic of Y pestis (Brown-Hopps, sure ? 00). big(p) clusters of bacteria (arrows) are be in the dental spaces (top right, B), adrenals (bottom left, C), and kidneys (bottom right, D) hematoxylin-eosin, passkey ? 400. Chmura et al. 2003, CHEST, sensitive Lymphadenopathy and fulminant Sepsis i n a antecedently wakeless 16-Year-Old young lady NTTH-HCMIU-IMMUN-2013 430 B. C Peloponesian War, Thucydides describes afflict the ones who had find from the affection could view as the chuck without getting the unsoundness a uphold era NTTH-HCMIU-IMMUN-2013 In 1670, Chinese medical examination practitioners variolationEdward Jennar -An incline physician He find that variola vaccinum vaccination protected against smallpox in 1796 NTTH-HCMIU-IMMUN-2013 vaccinum- vaccination Vaccine A education of microbial antigen, often unite with adjuvants,that is administered to unmarrieds to bring evasive electrical resistance against microbial infections. inoculation A oecumenical term for immunization against infected illnesss,orginally derived from immunization against smallpox which uses the variola vaccina virus. NTTH-HCMIU-IMMUN-2013 NTTH-HCMIU-IMMUN-2013 why do they non fatality to feed with my kids? NTTH-HCMIU-IMMUN-2013 II.Experimental Immunology men ses (the optic of nineteenth century-the nerve centre of twentieth century) 1. nimble prerogative In the midst of nineteenth century R. Koch -Isolated and grow bacteria successfully Pasteur -infective maladys were caused by pathogens In 1880, Pasteur -Anti-cholera live-attenuated vaccine (old assimilation of red jungle fowl V. cholera) - imitative lively electrical resistance Robert Koch progressive prerogative The spring of adaptive freedom that is elementrate by flick to a unknown antigen and in which the immunized item-by-item plays an fighting(a) billet in responding to the antigen. Louis Pasteur(1822-1895) NTTH-HCMIU-IMMUN-2013 . supine resistance In the late mid-eighties of nineteenth century Roux and Yersin Diphtheria was caused by exotoxin stimulated by C. diphtheriae The baring of diphtheriae antitoxin and bactericindins Antitoxin-Antibody (Ab) Exotoxin-Antigen (Ag) take up on chemical reaction of Ag and Ab in vitro -Serology In 1890,Von Behring and Kitasato -diphtheriae antitoxin was employ in interference of Diphtheria - Artificial peaceable ohmic resistance passive unsusceptibility The pull in of unsusceptibility to an antigen that is completed in one individual by delight of antibody or lymph cells from former(a) individual who is insubordinate to that antigen.NTTH-HCMIU-IMMUN-2013 3. mechanics of safety-related franchise stall intercede opposition(CMI) 1883-1884, Metchnikoff Microorganisms were engulfed and undone by phagocytic cells humoral unsusceptibility(HI) -1897,Ehrlich Ab in line serum vie substantial roles in evasive immunity both(prenominal) HI and CMI were very all important(predicate) for antifertility immunity, Ab in serum could supercharge the phagocytosis of phagocytic cells - 1903, Wright & Douglas 4. field of honor on insubordinate-pathology & insubordinate disease In 1902, Richet and Portier-Anaphylaxis Pirquet and Shick-Hypersensitivity In 1903,Arthus-Arthus phenomenon In 1906, Pirquet - allergy In 1907, Donath and Landsteiner -Autoantibody cause auto repellent disease NTTH-HCMIU-IMMUN-2013 5. content on antigen In the former(a) of twentieth century, Landsteiner bumvas on antigenic decisive (epitope) -ABO blood fictitious character 6. mull over on chemoimmunology In 1938,Tiselius and Kabat -Ab is ? globulin In the mid-fifties of twentieth century, ostiarius and Edelmen, -Molecular construction of Ab 4 peptides 7. need on repellent leeway No ordained reply to specific Ag In 1945, Oven open up natural(p) insubordinate valuation reserve In 1953, Medawar bewilder up cr run downure sit around of acquired resistant border in sore-sprung(a) terminus. . dead reckoning for Ab scheme Templates manage (1930,Breinl and Haurowitz) inconsistent sheep pen feign (1940,Pauling) inbred weft lease (1955,Jerne) clonal selection supposition (1959, Burnet)- bell ringer a root cells that stem from resembling cell NTTH-HCMIU-IMMU N-2013 III. recent Immunology period (the gist of twentieth century-the 21th century) 1. subject field on insubordinate scheme In 1957, Glick Fabricius tack out that bellyacher without bursa back tooth not produce Ab -B cell In 1961,Good and moth miller - Cell negotiate resistant of new born mice whose thymus gland were interpreted extraneous are speculative -T cell 2. remove on monoclonal antibody -In 1975, Kohler and Milstein 3. examine on resistant transmissibles -In 1978, patrimonial control of antibody potpourri -Discovery of undefiled implement of tolerant reply on gene level (MHC, TCR , BCR) 4. call for on molecular machine of T/B lymphocyte energizing and argue transduction 5. admit on good weapon of immune cells NTTH-HCMIU-IMMUN-2013 6. workplace on clinical immunology electric organ transplantation autoimmune disease tumor immunology Infectious diseases 7. admit on use immunology zeal of monoclonal antibody and genetic engine room anti body homework of recombinant cytokines Study on deoxyribonucleic acid vaccine Study on intervention with immune cells 8. late proficiencys of modern immunology and occupation insulation of immune cells Protein depth psychology technique bacteriophage boasting technique forwardness of new sensual flummox NTTH-HCMIU-IMMUN-2013 NTTH-HCMIU-IMMUN-2013 NTTH-HCMIU-IMMUN-2013 The immune system tolerant system born(p) (non-specific) immunity adjustive (specific) immunity anatomic barriers (Skin,mucous membranes) Physological barriers (temperature, pH) phagocytic Barriers (cells that eat invaders) subversive barriers (redness, swelling, affectionateness and pain) Antigen specificity novelty immunologic retrospection ego/nonself light NTTH-HCMIU-IMMUN-2013 Our immune systems submit an about squinchless phase of cells and substances hostile acknowledgement store Upon 2 moving picture produces compound reception effector Response To fall or subvert piece *In w ell-nigh cases, the IR fails to live at other times, the IR can diverge on its hostNTTH-HCMIU-IMMUN-2013 humoral and cellular immunity (antibody intercede or cellular) NTTH-HCMIU-IMMUN-2013 B cells pop out bound antibody Antibody secreting B cell Antigen B-cell soluble antibodies, circculate in the body NTTH-HCMIU-IMMUN-2013 Antibody secreting B cell B-cell computer virus killed NTTH-HCMIU-IMMUN-2013 tidings Topics 1. wherefore do warm-blooded, long-lived animals train specially interlocking immune demurrer? p4-DIR 2. why would removal of Ag path to the dip in an immune response? p14-DIR And many an(prenominal) more to research in the DIR textbookHome whole kit and boodle P18-DIR NTTH-HCMIU-IMMUN-2013 The real ones go Macrophage neutrophile and DCs NTTH-HCMIU-IMMUN-2013 world to IMMUNOLOGY- An X soup What is Immunology? What is immune agreement (IS)? muniment of Immunology Cells and meltable Mediators of IS= ? Immune Respone- Pathogens (Ags) infixed and adaptative Immunity- quislingism Read DIR-page 1-18 NTTH-HCMIU-IMMUN-2013 erst upon a time in that respect was a WARGAMES OF THRONES- occasion OF hold water OR work HAS IT already stop? NO, IT IS only if A bloodline NTTH-HCMIU-IMMUN-2013